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- Here (41)
- Worst Practices
- Pharmaceutical Industry Survey (2006)
- Unintended Bias and Errors of Interpretation
- Insecurities of the Highly Educated
- Attitudes Toward Risk & Uncertainty
- Diagnostic Template
- Retrospective Distortion
- Insecurities of the Highly Educated
- Occaam's Razor, Cheap Heuristic
- Artificial Deadlines or Deadline Bias
- Decision Making Biases
- Skunkworks
- WIP Counting
- Regrets
- Mirror Imaging
- Investment Behaviors
- Monetary Incentives
- Human Condition
- Regrets in Decision Making
- Escalation
- Inductive Probabilistic Reasoning
- Three Body Problem
- Recent Warming Reverses Long-Term Arctic Cooling
- Analogous Thinking
- DRGs and Process Optimization aka Sigma
- That Pile of Stuff
- Statistics and A>B
- Newsletter – R&D Operating Models (Vol. 1, No. 2)
- A Disturbing Thought
- Disconfirming Evidence, The Process
- Quants Inadmissible
- Quality and Effectiveness
- The Sandbox Challenge
- Pattern Recognition
- Franchise Benefits
- Mechanistic Behaviors
- Let 'em Fail!
- Shots on Goal
- All Your Eggs in One Basket
- Ouch!
- Productivity Not Profits
- Getting There (113)
- Behavior Fundamentals
- Obstacles
- Crises
- Incremental Changes - Lulls
- Blunders - Mistakes
- End Game
- Legalism (LEG)
- Freedom & Responsibility (F&R)
- Consequences (CON)
- Other People's Money (OPM)
- Competition (COM)
- Satisfaction (SAT)
- Revelation (REV)
- Arms-Length (ARM)
- Behavior Fundamentals Listing
- Discontinuous Discovery
- Imagine You're an Investor Faced with the Following Decision
- Flexibility of Pursuit in R&D
- Behavior Fundamentals Illustration
- Types of Tools
- Building Blocks of Eventual Success
- Tolerance for Ambiguity
- Domino Causality
- Tiers of Evidence
- Independent Evaluation Defined
- Trial by Jury
- Interocular Results
- Mini-Clini's
- Introduction, About Us
- Scope of Application
- Introduction, Maturity Matrix
- Caution, Organizational Behaviors
- Mgt. of Risk & Uncertainty, Maturity Matrix
- Evidence Gathering, Maturity Matrix
- Commentary, Maturity Matrix
- Organizational Behaviors, Maturity Matrix
- ESOPs As a Motivational Tool
- R&D Finance 101
- Training and Certification
- Genesis of World Class R&D
- R&D as a Trusted Partner
- There is No Metric for Creativity
- Portfolio Management and Investible Units
- Venture Management and Investible Units
- Franchise Management and Investible Units
- Commercial Management and Investible Units
- Operating Models Overview
- Elimination of Investigator Bias
- Disconfirming Evidence and Blockbuster Drugs
- It’s All About Personal Success
- No Blowin' Smoke
- No Excuses
- Real Progress
- Not a Numbers Game
- Making Good Leaders Great
- Mid-Game Overview
- Scientific Competitive Edge
- Free Market R&D
- Drug Safety and Grandma
- Theory vs. Empirical Results
- Inference then Observation
- Across-the-Board Cost Cuts
- Buffeting Winds - Examples of Protections
- Implementation
- R&D Productivity: A Dialog
- The R&D Narrative
- Tools & Techniques Crosswalk
- Intellectual Property Repository
- No Mechanics Allowed...
- Timely Halt to Untenable Pursuits
- Valuation Change Request
- Free-Format Proposal
- Franchisee-In-Charge
- Pay-for-Performance
- Get Everybody on the Same Page
- Many Routes to Success, Few to Failure
- Penicillin Breakthrough in the Production Facility
- We Let Partners Get Under Our Skin
- Commercialization Strategy
- Commercialization Overview
- Product Valuation, Commercial Equation
- Ratcheting Royalties
- Ties That Bind
- Assuaging Investor Anxieties
- Advantages of In-Sourcing
- Commentary on End-Game
- Intellectual Property in End-Game
- Employees in End-Game
- What About Success?
- How to End
- Why End?
- Why It Pays to End Well
- Laboratory vs. Field Studies
- You Get the Answer You Want
- R&D Strategy
- Case Study - Trial by Jury
- You Know You've Arrived When...
- Where to Look for New Tools
- How to Use Tools
- How to Implement Management Tools
- What to Look for in Tools
- Introduction to Management Tools & Techniques
- Why the World Class R&D Institute...
- What to Look for in Tools II
- Sustainability of Management Tools
- World Class R&D Going Forward
- New Organizational Forms
- New Money
- New Men
- Men, Machines and Modern Times - Elting Elmore Morison
- Chance, Nécessité, et Naïveté
- World Class R&D Alternate to Pharma in Decline
- Windfalls Can Be a Curse...
- There (94)
- Means Toward Effectiveness
- Compared to Manufacturing 1(2), Key Areas of Focus
- Introduction, Governance
- Compared to Manufacturing 2(2), Key Areas of Focus
- Components, Governance
- Principles, Governance
- Decision Authority, Governance
- Structure, Governance
- Behaviors, Key Areas of Focus
- Sustainability, Governance
- Oversight, Governance
- Introduction, Evidence Gathering
- Commentary, Governance
- Work Practices, Evidence Gathering
- Compulsories, Evidence Gathering
- Role of Governance, Evidence Gathering
- Scope, Evidence Gathering
- Challenges, Evidence Gathering
- Behaviors, Evidence Gathering
- Background & Understanding, Mgt. of Risk & Uncertainty
- Product Safety, Evidence Gathering
- Compulsories, Mgt. of Risk & Uncertainty
- Introduction, Mgt. of Risk & Uncertainty
- Decision Structures, Mgt. of Risk & Uncertainty
- Work Practices, Mgt. of Risk & Uncertainty
- Role of Governance, Mgt. of Risk & Uncertainty
- Introduction, Organizational Behaviors
- Behavior Fundamentals, Organizational Behaviors
- Work Practices, Organizational Behaviors
- Signals, Organizational Behaviors
- Evidence-Based Management, Organizational Behaviors
- Investible Units
- Applicability of the Prescriptions, Key Areas of Focus
- Illogical R&D
- Buddy N.
- Bodies of Evidence
- Newsletter – R&D Operating Models (Vol. 1, No. 2)
- A Disturbing Thought
- Supply of high caliber investments
- Create a Scientific Competitive Advantage
- Rights of First Refusal
- Fab Five
- Boot Camp
- Team Passions and Motivations
- Man in the Gray Flannel Suit
- What Can Possibly Go Right?
- Pre-game Sets the Stage for Success
- Franchise Fees & The Tyrant
- Knowledge Trading
- Use of Allies in R&D Protection
- C-level Behaviors
- R&D Protection Mechanisms
- Mutually Assured Destruction - The Nuclear Option
- Buffeting Winds of the Corporation - Introduction
- Why the World Class R&D Institute...
- Bringing It All Together - Franchise Capital Management
- The Island Nation of R&D Inc.
- Introduction to Franchise Capital Management
- From Unpredictable R&D to Predictable Investor Returns
- It's a Package Deal
- Pig Farmers, Prostitutes and Leverage
- We Love Investor Exits
- You Have to See It to Believe It
- Execution is the Key to Success
- Retail Investors As Predictable Funding
- It's a Vast Untapped Market
- It's a good thing we don't get all the government we pay for
- Mother Nature Left the Building
- Milestones
- Why Push As Far As Commercialization?
- The Power of Ownership
- The POW Priest
- Watchdog
- Why Blockbusters?
- The Cooperative Solution
- Valuation of Intellectual Capital
- Cautions
- Rules
- Citizens
- Community
- Reflection-in-Action
- Insurance
- Intellectual Capital Valuation LLC
- Perfect Storms
- Trust and Redemption
- Intellectual Capital
- Systemic Risks
- Voting Constructs
- The Challenge of Brash Citizens
- We Do Not Commit Investors for the Duration
- Special Interest Groups
- Results That Stand the Test of Time
- Separation of Voting Rights from Cash Flow
- One Person, One Vote, No Proxies
- Turmoil (160)
- What about these alternate views of industrial R&D?
- Passionate Research Careers
- The Devil Incarnate
- Behaviors are ugly
- How Science Progresses
- Signals in R&D
- Commercialization
- Black Swan
- Build It and They'll Come
- Generalization
- Checklists, Cheap Heuristics
- Interocular Results
- Humor Submission
- Freedom and Dissention
- Locke's Madman
- Measuring Interim Progress in R&D
- Case Study – #006 R&D Acquisitions
- Tyranny of Models
- What do I get for all my effort in World Class R&D?
- World Class R&D Budgeting
- Leaky Pipes
- Smaller is Better? No, Start-Ups are Small.
- We Use Comparison Studies to Fool Others...
- Illogical R&D
- The 30-70 Rule
- Personalized Animal Studies
- Elimination of Investigator Bias
- How much does it cost for that train to move a ton of freight?
- Mysteries and R&D
- Buddy N.
- A Disturbing Thought
- Efficiency vs. Effectiveness
- Disconfirming Evidence and Blockbuster Drugs
- Heterogeneity of the Placebo Effect
- Punishers, Dissenters and Brainiacs
- The Sandbox Challenge
- The Mystery of Patient Compliance Levels
- It’s All About Personal Success
- No Blowin' Smoke
- No Excuses
- Real Progress
- Not a Numbers Game
- Making Good Leaders Great
- Mid-Game Overview
- Franchise Fees & The Tyrant
- Scientific Competitive Edge
- Knowledge Trading
- Behaviors Couldn't Get Any Worse
- Free Market R&D
- Drug Safety and Grandma
- Theory vs. Empirical Results
- Opening Session Remarks, DIA 2010
- World Class R&D, Take II
- Use of Allies in R&D Protection
- C-level Behaviors
- R&D Protection Mechanisms
- Buffeting Winds - Examples of Protections
- Mutually Assured Destruction - The Nuclear Option
- Implementation
- Buffeting Winds of the Corporation - Introduction
- Pattern Recognition
- World Class R&D, Take III
- Gestalt
- Tools & Techniques Crosswalk
- Franchise Benefits
- Intellectual Property Repository
- No Mechanics Allowed...
- Timely Halt to Untenable Pursuits
- Valuation Change Request
- Free-Format Proposal
- Franchisee-In-Charge
- Pay-for-Performance
- Get Everybody on the Same Page
- Many Routes to Success, Few to Failure
- Penicillin Breakthrough in the Production Facility
- We Let Partners Get Under Our Skin
- Commercialization Strategy
- Commercialization Overview
- Product Valuation, Commercial Equation
- Ratcheting Royalties
- Ties That Bind
- Assuaging Investor Anxieties
- Advantages of In-Sourcing
- Commentary on End-Game
- Intellectual Property in End-Game
- Employees in End-Game
- What About Success?
- How to End
- Why End?
- Why It Pays to End Well
- Tyranny of Efficiency
- Laboratory vs. Field Studies
- You Get the Answer You Want
- R&D Strategy
- What We Learn from McD
- Case Study - Trial by Jury
- You Know You've Arrived When...
- Where to Look for New Tools
- How to Use Tools
- How to Implement Management Tools
- What to Look for in Tools
- Introduction to Management Tools & Techniques
- Why the World Class R&D Institute...
- What to Look for in Tools II
- Sustainability of Management Tools
- Government Response to Pharma in Decline - Editorial
- World Class R&D Going Forward
- Today's Pharmaceutical Industry Going Forward
- New Organizational Forms
- New Money
- New Men
- Phases of Industrial Growth and Decline
- Men, Machines and Modern Times - Elting Elmore Morison
- Chance, Nécessité, et Naïveté
- World Class R&D Alternate to Pharma in Decline
- Decline of the Pharmaceutical Industry
- Bringing It All Together - Franchise Capital Management
- The Island Nation of R&D Inc.
- Introduction to Franchise Capital Management
- From Unpredictable R&D to Predictable Investor Returns
- It's a Package Deal
- Pig Farmers, Prostitutes and Leverage
- We Love Investor Exits
- You Have to See It to Believe It
- Execution is the Key to Success
- Retail Investors As Predictable Funding
- It's a Vast Untapped Market
- It's a good thing we don't get all the government we pay for
- Mother Nature Left the Building
- Milestones
- Why Push As Far As Commercialization?
- Shots on Goal
- The Power of Ownership
- The POW Priest
- Watchdog
- Why Blockbusters?
- The Cooperative Solution
- Valuation of Intellectual Capital
- Cautions
- Rules
- Citizens
- Community
- Breathing Life into Intellectual Capital
- Reflection-in-Action
- Insurance
- Intellectual Capital Valuation LLC
- Perfect Storms
- Trust and Redemption
- Intellectual Capital
- All Your Eggs in One Basket
- Systemic Risks
- Voting Constructs
- Ouch!
- The Challenge of Brash Citizens
- We Do Not Commit Investors for the Duration
- Special Interest Groups
- Results That Stand the Test of Time
- Separation of Voting Rights from Cash Flow
- One Person, One Vote, No Proxies
- Productivity Not Profits
- Nuggets (3)
- Governance (125)
- Flexibility of Pursuit in R&D
- Independent Evaluation Defined
- WIP Counting
- Regrets
- Escalation
- Introduction, Governance
- Components, Governance
- Principles, Governance
- Decision Authority, Governance
- Structure, Governance
- Sustainability, Governance
- Oversight, Governance
- Commentary, Governance
- ESOPs As a Motivational Tool
- R&D Finance 101
- Leaky Pipes
- Investible Units
- Supply of high caliber investments
- Create a Scientific Competitive Advantage
- Rights of First Refusal
- Fab Five
- Boot Camp
- Team Passions and Motivations
- Man in the Gray Flannel Suit
- What Can Possibly Go Right?
- Pre-game Sets the Stage for Success
- It’s All About Personal Success
- No Blowin' Smoke
- No Excuses
- Real Progress
- Not a Numbers Game
- Making Good Leaders Great
- Mid-Game Overview
- Franchise Fees & The Tyrant
- Scientific Competitive Edge
- Knowledge Trading
- Free Market R&D
- Use of Allies in R&D Protection
- Mutually Assured Destruction - The Nuclear Option
- Buffeting Winds of the Corporation - Introduction
- The R&D Narrative
- Tools & Techniques Crosswalk
- Franchise Benefits
- Intellectual Property Repository
- Timely Halt to Untenable Pursuits
- Valuation Change Request
- Free-Format Proposal
- Franchisee-In-Charge
- Pay-for-Performance
- Get Everybody on the Same Page
- Many Routes to Success, Few to Failure
- Penicillin Breakthrough in the Production Facility
- Commercialization Strategy
- Commercialization Overview
- Product Valuation, Commercial Equation
- Ratcheting Royalties
- Ties That Bind
- Assuaging Investor Anxieties
- Advantages of In-Sourcing
- Commentary on End-Game
- Intellectual Property in End-Game
- What About Success?
- How to End
- Why End?
- Why It Pays to End Well
- Laboratory vs. Field Studies
- R&D Strategy
- Case Study - Trial by Jury
- You Know You've Arrived When...
- Where to Look for New Tools
- How to Use Tools
- How to Implement Management Tools
- What to Look for in Tools
- Introduction to Management Tools & Techniques
- Why the World Class R&D Institute...
- What to Look for in Tools II
- Sustainability of Management Tools
- World Class R&D Going Forward
- Today's Pharmaceutical Industry Going Forward
- New Organizational Forms
- New Money
- New Men
- Men, Machines and Modern Times - Elting Elmore Morison
- Chance, Nécessité, et Naïveté
- World Class R&D Alternate to Pharma in Decline
- Bringing It All Together - Franchise Capital Management
- The Island Nation of R&D Inc.
- Introduction to Franchise Capital Management
- From Unpredictable R&D to Predictable Investor Returns
- It's a Package Deal
- Pig Farmers, Prostitutes and Leverage
- We Love Investor Exits
- You Have to See It to Believe It
- Execution is the Key to Success
- Retail Investors As Predictable Funding
- It's a Vast Untapped Market
- It's a good thing we don't get all the government we pay for
- Mother Nature Left the Building
- Milestones
- Why Push As Far As Commercialization?
- Shots on Goal
- The Power of Ownership
- The POW Priest
- Watchdog
- Why Blockbusters?
- The Cooperative Solution
- Valuation of Intellectual Capital
- Cautions
- Rules
- Citizens
- Community
- Reflection-in-Action
- Insurance
- Intellectual Capital Valuation LLC
- Perfect Storms
- Trust and Redemption
- Intellectual Capital
- Systemic Risks
- Voting Constructs
- The Challenge of Brash Citizens
- We Do Not Commit Investors for the Duration
- Special Interest Groups
- Results That Stand the Test of Time
- Separation of Voting Rights from Cash Flow
- One Person, One Vote, No Proxies
- Evidence Gathering (38)
- Means Toward Effectiveness
- Retrospective Distortion
- Tolerance for Ambiguity
- Domino Causality
- Emergent Properties
- Interocular Results
- Mirror Imaging
- Mini-Clini's
- Inductive Probabilistic Reasoning
- Introduction, Evidence Gathering
- Work Practices, Evidence Gathering
- Compulsories, Evidence Gathering
- Role of Governance, Evidence Gathering
- Scope, Evidence Gathering
- Challenges, Evidence Gathering
- Behaviors, Evidence Gathering
- Product Safety, Evidence Gathering
- Evidence Gathering, Maturity Matrix
- Three Body Problem
- Recent Warming Reverses Long-Term Arctic Cooling
- Analogous Thinking
- Tyranny of Models
- Statistics and A>B
- Elimination of Investigator Bias
- Bodies of Evidence
- Disconfirming Evidence, The Process
- Disconfirming Evidence and Blockbuster Drugs
- Quants Inadmissible
- Quality and Effectiveness
- Knowledge Trading
- Theory vs. Empirical Results
- Inference then Observation
- Pattern Recognition
- No Mechanics Allowed...
- We Let Partners Get Under Our Skin
- You Get the Answer You Want
- Execution is the Key to Success
- Ouch!
- Risk and Uncertainty (15)
- Attitudes Toward Risk & Uncertainty
- Occaam's Razor, Cheap Heuristic
- Checklists, Cheap Heuristics
- Trial by Jury
- Artificial Deadlines or Deadline Bias
- Regrets in Decision Making
- Background & Understanding, Mgt. of Risk & Uncertainty
- Compulsories, Mgt. of Risk & Uncertainty
- Introduction, Mgt. of Risk & Uncertainty
- Decision Structures, Mgt. of Risk & Uncertainty
- Work Practices, Mgt. of Risk & Uncertainty
- Role of Governance, Mgt. of Risk & Uncertainty
- Mgt. of Risk & Uncertainty, Maturity Matrix
- Drug Safety and Grandma
- Execution is the Key to Success
- Organizational Behaviors (25)
- Case Study – #005 Colleagues at Each Other’s Throats
- Behavior Fundamentals
- Behaviors are ugly
- Legalism (LEG)
- Other People's Money (OPM)
- Revelation (REV)
- Behavior Fundamentals Listing
- Pharmaceutical Industry Survey (2006)
- Insecurities of the Highly Educated
- Types of Tools
- Insecurities of the Highly Educated
- Monetary Incentives
- Human Condition
- Introduction, Organizational Behaviors
- Work Practices, Organizational Behaviors
- Behavior Fundamentals, Organizational Behaviors
- Signals, Organizational Behaviors
- Evidence-Based Management, Organizational Behaviors
- Caution, Organizational Behaviors
- Organizational Behaviors, Maturity Matrix
- C-level Behaviors
- R&D Protection Mechanisms
- Buffeting Winds - Examples of Protections
- How to Implement Management Tools
- Execution is the Key to Success
